WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Cardiac muscle contraction       ID:04260
C=77; O=5; E=0.17; R=28.87; rawP=9.01e-07; adjP=1.62e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114854 NA TNNC1 troponin C type 1 (slow) 7134 ENSG00000114854
2  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
3  ENSG00000140416 NA TPM1 tropomyosin 1 (alpha) 7168 ENSG00000140416
4  ENSG00000198467 NA TPM2 tropomyosin 2 (beta) 7169 ENSG00000198467
5  ENSG00000159251 NA ACTC1 actin, alpha, cardiac muscle 1 70 ENSG00000159251


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=7; E=0.48; R=14.61; rawP=5.72e-07; adjP=1.62e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140285 NA FGF7 fibroblast growth factor 7 2252 ENSG00000140285
2  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
3  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
4  ENSG00000083457 NA ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 3682 ENSG00000083457
5  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
6  ENSG00000126458 NA RRAS related RAS viral (r-ras) oncogene homolog 6237 ENSG00000126458
7  ENSG00000077782 NA FGFR1 fibroblast growth factor receptor 1 2260 ENSG00000077782


Database:KEGG pathway       Name:Hypertrophic cardiomyopathy (HCM)       ID:05410
C=83; O=5; E=0.19; R=26.78; rawP=1.31e-06; adjP=1.62e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114854 NA TNNC1 troponin C type 1 (slow) 7134 ENSG00000114854
2  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
3  ENSG00000140416 NA TPM1 tropomyosin 1 (alpha) 7168 ENSG00000140416
4  ENSG00000198467 NA TPM2 tropomyosin 2 (beta) 7169 ENSG00000198467
5  ENSG00000159251 NA ACTC1 actin, alpha, cardiac muscle 1 70 ENSG00000159251


Database:KEGG pathway       Name:Dilated cardiomyopathy       ID:05414
C=90; O=5; E=0.20; R=24.70; rawP=1.96e-06; adjP=1.81e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114854 NA TNNC1 troponin C type 1 (slow) 7134 ENSG00000114854
2  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
3  ENSG00000140416 NA TPM1 tropomyosin 1 (alpha) 7168 ENSG00000140416
4  ENSG00000198467 NA TPM2 tropomyosin 2 (beta) 7169 ENSG00000198467
5  ENSG00000159251 NA ACTC1 actin, alpha, cardiac muscle 1 70 ENSG00000159251


Database:KEGG pathway       Name:Wnt signaling pathway       ID:04310
C=150; O=5; E=0.34; R=14.82; rawP=2.37e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113575 NA PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 5515 ENSG00000113575
2  ENSG00000177606 NA JUN jun proto-oncogene 3725 ENSG00000177606
3  ENSG00000145349 NA CAMK2D calcium/calmodulin-dependent protein kinase II delta 817 ENSG00000145349
4  ENSG00000161202 NA DVL3 dishevelled, dsh homolog 3 (Drosophila) 1857 ENSG00000161202
5  ENSG00000080815 NA PSEN1 presenilin 1 5663 ENSG00000080815


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=6; E=0.73; R=8.18; rawP=9.88e-05; adjP=0.0005
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140285 NA FGF7 fibroblast growth factor 7 2252 ENSG00000140285
2  ENSG00000177606 NA JUN jun proto-oncogene 3725 ENSG00000177606
3  ENSG00000161202 NA DVL3 dishevelled, dsh homolog 3 (Drosophila) 1857 ENSG00000161202
4  ENSG00000168610 NA STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 6774 ENSG00000168610
5  ENSG00000163513 NA TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 7048 ENSG00000163513
6  ENSG00000077782 NA FGFR1 fibroblast growth factor receptor 1 2260 ENSG00000077782


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=4; E=0.25; R=15.88; rawP=0.0001; adjP=0.0005
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
2  ENSG00000113575 NA PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 5515 ENSG00000113575
3  ENSG00000145349 NA CAMK2D calcium/calmodulin-dependent protein kinase II delta 817 ENSG00000145349
4  ENSG00000129055 NA ANAPC13 anaphase promoting complex subunit 13 25847 ENSG00000129055


Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=4; E=0.30; R=13.47; rawP=0.0002; adjP=0.0009
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113575 NA PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 5515 ENSG00000113575
2  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
3  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
4  ENSG00000126458 NA RRAS related RAS viral (r-ras) oncogene homolog 6237 ENSG00000126458


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=5; E=0.60; R=8.29; rawP=0.0004; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140285 NA FGF7 fibroblast growth factor 7 2252 ENSG00000140285
2  ENSG00000177606 NA JUN jun proto-oncogene 3725 ENSG00000177606
3  ENSG00000126458 NA RRAS related RAS viral (r-ras) oncogene homolog 6237 ENSG00000126458
4  ENSG00000163513 NA TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 7048 ENSG00000163513
5  ENSG00000077782 NA FGFR1 fibroblast growth factor receptor 1 2260 ENSG00000077782


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=4; E=0.45; R=8.89; rawP=0.0011; adjP=0.0041
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
2  ENSG00000177606 NA JUN jun proto-oncogene 3725 ENSG00000177606
3  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
4  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).